Overview of chromatin regulatory processes during surface ectodermal development and homeostasis. Meagan C. Branch, Madison Weber, Meng-Yen Li, Pooja Flora, Elena Ezhkova.

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Dev Bio 2024, 155, doi: 10.1016/j.ydbio.2024.07.001

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Two new students from the Mount Sinai CEYE (Center for Excellence in Youth Education) program have joined our lab: Julia Gross and Leo Mazur. We are excited to have you both!

We said goodbye to our previous CEYE scholar, Alua, who will be attending Columbia University in the fall. Congratulations, Alua, and good luck!

Meagan and Maria attended the Society for Investigative Dermatology meeting in Dallas, Texas. Maria and Meagan both presented posters, and Meagan gave a talk on her research in wound healing.

Nazifa Salsabeel joined the lab as Ph.D. student. She will be studying epigenetic regulation and drug targeting in Merkel cell carcinoma! Welcome!

Meagan was awarded an NRSA F31 award from National Institute of Arthritis and Musculoskeletal Disease for the study of transcriptional regulation of wound healing. Congratulations!

Elena presented a lecture at the Skin Symposium at University of California Irvine.

Elena presented a lecture at Sanford Stem Cell Discovery Center at University of San Diego.

Elena presented activities and resources available through the Mount Sinai SBDRC at the SBDRC 6 from 6 meeting!

Madison was awarded an NRSA F31 award from the National Cancer Institute to study Merkel cell carcinoma tumorigenesis. Congratulations!

Elena presented a talk to the dermatology department at Northwestern University!

Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

Nguyen MB, Flora P, Branch MC, Weber M, Zheng XY, Sivan U, Joost S, Annusver K, Zheng D, Kasper M, Ezhkova E.

Sci Adv. 2024 Jan 19;10(3):eadi5791. doi: 10.1126/sciadv.adi5791. Epub 2024 Jan 19.

Defining the fate trajectory of eccrine gland formation.
Branch MC, Ezhkova E.

Dev Cell. 2024 Jan 8;59(1):1-3. doi: 10.1016/j.devcel.2023.12.004.

Cleavage Under Targets & Release Using Nuclease (CUT&RUN) of Histone Modifications in Epidermal Stem Cells of Adult Murine Skin.

Flora P, Ezhkova E.

Methods Mol Biol. 2024;2736:9-21. doi: 10.1007/7651_2023_499.

The lab attended the New York Skin Club meeting, where Pooja presented a talk

Elena presented a talk to Northwestern University's pathology department!

Megha Padubidri joined the lab as a Master's student! She will be working on the epigenetic regulation of wound healing. Welcome!

Maria attended the SACNAS meeting in Portland, Oregon, supported by the Mount Sinai Diversity Equity and Inclusion office.

Meagan presented short talk at the Montagna Symposium on the Biology of Skin in Oregon! She was awarded the Director's Award for Diversity. Congratulations!!

We attended the IRM/CDRB departmental retreat. Pooja presented a talk, and Meng Yen presented a speed poster. Well done!

Yudong Zhou joined the laboratory as a Master's student. He will work on studies of Merkel cell biology. Welcome, Yudong!

Updates in SJS/TEN: collaboration, innovation, and community.

Front Med (Lausanne). 2023 Oct 11;10:1213889. doi: 10.3389/fmed.2023.1213889. eCollection 2023.

Elena and Pooja attended the 5th Aegean Stem Cell Conference in Greece. Pooja presented a poster, and Elena gave a talk!

Madison presented a poster at the Cold Spring Harbor Cancer Biology: Microenvironment & Metastasis meeting!

Meagan was selected for a short talk at the Montagna Symposium on the Biology of Skin in Oregon! Congratulations!

Maria was awarded a T32 predoctoral training fellowship from the Dermatology depatment. We are very proud!

Elena returned to Japan as a member of the organizing committee for the ISID meeting in Tokyo. See photos from both her trips here!

Elena went to Barcelona, Spain to present at the Gordon Research Conferences: Epithelial Differentiation and Keratinization meeting. She was also a vice-chair of this GRC meeting.

Meng Yen, Minh, and Pooja attended the Cold Spring Harbor Laboratories 87th Stem Cells Symposium and even presented posters!

Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

 Michelle Khattri, Yutaka Amako, Julia R Gibbs, Joseph L Collura, Reety Arora, Alexis Harold, Meng Yen Li, Paul W Harms, Elena Ezhkova, Masahiro Shuda

Maria successfully defended her thesis proposal and is now a PhD candidate! Congratulations!

Merkel Cell Polyomavirus-Mediated Reprogramming in Adult Merkel Cell Progenitors

Madison Weber, Minh Nguyen, Meng-Yen Li, Pooja Flora, Masahiro Shuda, Elena Ezhkova.

Pooja was awarded a Pathway to Independence Award (K99/R00) from the NIH. This is an extremely competitive fellowship award, and we are so proud of her!

Meng Yen presented a selected talk at the Skin Center (SBDRC) Retreat! See a photo here!

Elena traveled to Okinawa, Japan as part of the committee organizing the International Society for Investigative Dermatology meeting! See photos from both her trips here!

Madison gave a selected talk at the New York Skin Club meeting! Great job on her first time. See a photo here!

We also reunited with lab alumni Evan Bardot and Carmit Bar-- thank you both for for returning to speak about your careers at Nature and ImPress since the lab.

Elena gave a talk at the NYU Cancer Center!

Madison gave a selected talk and Meagan gave a speed poster presentation at the annual BFSCI/CDRB joint department retreat. Congratulations to both of them, and great job!

Elena gave a talk at the Center for Cutaneous Biology and Immunology, Henry Ford Health System, Wayne State University

Pooja Flora received a Transition-to-Independence grant from the P30-supported SBDRC at Mount Sinai. Congratulations on this achievement!

Congratulations to Meagan on passing her Thesis Proposal Exam and becoming a PhD candidate!

Elena gave a seminar at the University of Toronto, Collaborative Specialization in Developmental Biology!

Elena gave a seminar on epigenetic regulation of skin stem cells at the 3rd Fusion Conference on Epigenetics in Cancun, Mexico. See her photo here!

Great to meet former Ezhkova lab members at a conference! Julian was a postdoctoral fellow in our lab and is now an assistant professor at UNAM Mexico. Wonderful to say hi!

Pooja and Meng Yen gave talks at the SID Annual Meeting in Portland, Oregon. Congratulations to both! Check out these pictures!

Elena gave a USC Stem Cell Distinguished Seminar.

Pooja presented her research on hair follicle stem cell regulation at the SBDRC at Mount Sinai annual retreat! Learn more about the skin center here!

Elena spoke at the FASEB Catalyst Conferences, Form and Function - Stem Cells In Action.

Elena presented a seminar on UV-induced epidermal pigmentation for the PanAmerican Societ for Pigment Cell Research (PASPCR).

Elena gave a seminar for the NIH Transcription Interest Group, NIH/NIDDK.

Welcome graduate student Maria Mercedes to the lab!

Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration.

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Pooja Flora, Meng-Yen Li, Phillip M. Galbo Jr., Maider Astorkia, Deyou Zheng, and Elena Ezhkova.

Congratulations to Pooja for presenting her research on Polycomb regulation of hair follicle stem cells at the NY Skin Club!

Congratulations Meng Yen for receiving the NYSTEM Institutional Training postdoctoral fellowship for his studies investigating the epigenetic mechanisms of skin photoaging!

Welcome research associate Eden Teferi to the lab!

Congratulations to Meng Yen for being selected for a talk at the BFSCI/CDRB joint retreat!

Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells

Pooja Flora, Gil Dalal, Idan Cohen, and Elena Ezhkova

Welcome Postdoctoral Fellow Radhika Rao to the lab!

Elena and Meng Yen were interviewed by MedicalResearch about our recent publication in

Developmental Cell. Thanks to MedicalResearch for giving us this opportunity!

The interview can be found at this link: https://medicalresearch.com/author-interviews/mt-sinai-researchers-explore-polycomb-induced-skin-pigmentation-without-uv-light/58113/

Elena chatted with HCPLive about our recent publication on epigenetic regulation of epidermal pigmentation. The interview can be found using this link: https://www.hcplive.com/view/elena-ezhkova-phd-epigenetic-changes-uv-exposure

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

Meng-Yen Li, Pooja Flora, Hong Pu, Carmit Bar,  Jose Silva,  Idan Cohen, Phillip M Galbo Jr, Hequn Liu, Xufen Yu, Jian Jin, Haruhiko Koseki, John A D'Orazio, Deyou Zheng, Elena Ezhkova

Congratulations Meagan for receiving an NIH/NIAMS Diversity Supplement Award!

Elena gave a virtual talk at the SJS/TEN 2021 Conference. The title of her talk was “The role of epigenomics in skin health and inflammation.”

Congratulations to Madison for successfully defending her thesis proposal. Madison is now officially a PhD candidate!

Meng Yen gave a talk at the GRC Series Webinar. The title of his talk was “UV-induced reduction in Polycomb repression promotes epidermal pigmentation.”

Elena gave a virtual seminar at the UPenn Epigenetics Institute. The title of her talk was “Epidermal Stem Cell and Their Epigenetic Regulation."

Congratulations Carmit for presenting at NYC chromatin club and winning a CUTANA CUT&RUN kit for an outstanding presentation!

Polycomb complexes redundantly maintain epidermal stem cell identity during development

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Idan Cohen* , Carmit Bar*, Hequn Liu, Victor J Valdes, Dejian Zhao, Phillip M Galbo Jr, Jose M Silva, Haruhiko Koseki, Deyou Zheng, Elena Ezhkova 

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Welcome, Meagan Branch!

Regulatory mechanisms governing epidermal stem cell function during development and homeostasis

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Pooja Flora, Elena Ezhkova

Achievement award ceremony is going virtual! May 14, 2020 3:00pm

https://icahn.mssm.edu/livestream

Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions. Cohen I, Bar C, Ezhkova E.

Congratulations Pooja for winning the NYSTEM training grant for stem cell biology  December 17, 2019

We were proud to be a part of the BFSCI Skin Club organizing committee!

December 9, 2019, Icahn School of Medicine at Mount Sinai

Welcome, Madison Weber!

Congratulations Carmit for winning the BFSCI Skin Club best poster presentation!  December 9, 2019, Icahn School of Medicine at Mount Sinai

Congratulations to Carmit for the publication "Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression"

Idan Cohen presented at the GRC.

Carmit Bar presented at the GRS

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https://www.grc.org/epithelial-differentiation-and-keratinization-conference/2019/

https://www.grc.org/epithelial-differentiation-and-keratinization-grs-conference/2019/

July 6-12, The Jordan hotel at Sunday River, ME

Idan Cohen presents at the GRC.

Carmit Bar presents at the GRS

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https://www.grc.org/epithelial-differentiation-and-keratinization-conference/2019/

https://www.grc.org/epithelial-differentiation-and-keratinization-grs-conference/2019/

July 6-12, The Jordan hotel at Sunday River, ME

https://www.sidannualmeeting.org/

Congratulations to Minh for the publication "Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling"

Congratulations to Idan for the publication "PRC1 preserves epidermal tissue integrity independently of PRC2"