Publications

Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M

Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201907154. doi: 10.1073/pnas.1907154116

 

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Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression

Bar CCohen IZhao DPothula VLitskevitch AKoseki H Zheng DEzhkova E.

 

Cell Rep. 2019 Jul 2;28(1):257-266.e5. doi: 10.1016/j.celrep.2019.06.011

 

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Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

Miroshnikova YACohen IEzhkova EWickström SA.


Curr Opin Genet Dev. 2019 May 18;55:46-51. doi: 10.1016/j.gde.2019.04.014

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Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signaling

Nguyen MBValdes VJCohen IPothula VZhao DZheng DEzhkova E.

 

Exp Dermatol. 2019 Feb 13. doi: 10.1111/exd.13901

 

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PRC1 preserves epidermal tissue integrity independently of PRC2

Cohen IZhao DMenon GNakayama MKoseki HZheng DEzhkova E.

 

Genes Dev. 2018 Dec 19. doi: 10.1101/gad.319939.118

 

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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Nguyen MBCohen IKumar VXu ZBar CDauber-Decker KLTsai PCMarangoni PKlein ODHsu YCChen TMikkola MLEzhkova E.

 

Nat Commun. 2018 Jun 13;9(1):2333. doi: 10.1038/s41467-018-04399-y.

PMID: 29899403

 

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PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB1, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E

Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005.

PMID: 29727681

 

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miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy

Rodriguez-Barrueco R1,2, Nekritz EA1, Bertucci F3, Yu J4, Sanchez-Garcia F5, Zeleke TZ1, Gorbatenko A1, Birnbaum D3, Ezhkova E6, Cordon-Cardo C1, Finetti P3, Llobet-Navas D1,2, Silva JM1

Genes Dev. 2017 Mar 15;31(6):553-566. doi: 10.1101/gad.292318.116

PMID:28404630

 

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Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

Zhang B, Tsai PC, Gonzalez-Celeiro M, Chung O, Boumard B, Perdigoto CN, Ezhkova E, Hsu YC.

Genes Dev. 2016 Oct 15;30(20):2325-2338. Epub 2016 Nov 2.

PMID: 27807033

 

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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development

Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E

PLoS Genet. 2016 Jul 14;12(7):e1006151. doi: 10.1371/journal.pgen.1006151. eCollection 2016 Jul

PMID:27414999

 

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The mesenchymal transcription factor SNAI-1 instructs human liver specification

Goldman O, Valdes VJ, Ezhkova E Gouon-Evans V

Stem Cell Res. 2016 Jul;17(1):62-8. doi: 10.1016/j.scr.2016.05.007. Epub 2016 May 21.

PMID:27240252

 

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Molecular Mechanisms Regulating Stem Cells Fate

Chen YG, Ezhkova E, Ostankovitch M.

J Mol Biol. 2016 Apr 10;428(7):1407-8. doi: 10.1016/j.jmb.2016.03.011. Epub 2016 Mar 18

PMID:26996938

 

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Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E.

J Invest Dermatol. 2016 Aug;136(8):1647-55. doi: 10.1016/j.jid.2016.02.809. Epub 2016 Mar 16.

PMID:26994968

 

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Cbx4: A new guardian of p63's domain of epidermal control.

Cohen I, Ezhkova E

J Cell Biol. 2016 Jan 4;212(1):9-11. doi: 10.1083/jcb.201512032. Epub 2015 Dec 28

PMID:26711501

 

 

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Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF

 

Genes Dev. 2015 Jan 15;29(2):144-56. doi: 10.1101/gad.249748.114. Epub 2014 Dec 29

 

PMID:25547114 

 

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Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network

Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E

Development. 2014 Dec;141(24):4690-6. doi: 10.1242/dev.112169

PMID:25468937

 

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The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells

Llobet-Navas D, Rodriguez-Barrueco R, de la Iglesia-Vicente J, Olivan M, Castro V, Saucedo-Cuevas L, Marshall N, Putcha P, Castillo-Martin M, Bardot E, Ezhkova E, Iavarone A, Cordon-Cardo C, Silva JM.

 

Mol Cell Biol. 2014 Dec 1;34(23):4216-31. doi: 10.1128/MCB.00611-14. Epub 2014 Sep 29

 

PMID:25266660

 

 

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The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM

Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17

PMID:24636986

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Epigenetic regulation of epidermal differentiation

Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E.

Cold Spring Harb Perspect Med. 2014 Feb 1;4(2). pii: a015263. doi: 10.1101/cshperspect.a015263

PMID:24492849

 

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Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

Bardot ES, Valdes VJ, Zhang J, Perdigoto CN, Nicolis S, Hearn SA, Silva JM, Ezhkova E.

EMBO J. 2013 Jul 17;32(14):1990-2000. doi: 10.1038/emboj.2013.110. Epub 2013 May 14

PMID:23673358

 

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SWItching on epidermal cell fate

Perdigoto CN1, Bardot ES, Ezhkova E.

Cell Stem Cell. 2013 Feb 7;12(2):141-2. doi: 10.1016/j.stem.2013.01.011.

PMID:23395438

 

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Epigenetic regulation of skin: focus on the Polycomb complex

Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E

 

Cell Mol Life Sci. 2012 Jul;69(13):2161-2172. doi: 10.1007/s00018-012-0920-x

PMID:22314499


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Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat

Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.

Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.

 

PMID:21680712

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EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E.

Genes Dev. 2011 Mar 1;25(5):485-98. doi: 10.1101/gad.2019811. Epub 2011 Feb 11

PMID:21317239

 

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Regenerative medicine: An eye to treating blindness

Ezhkova E, Fuchs E.

Nature. 2010 Jul 29;466(7306):567-8. doi: 10.1038/466567a

 

PMID:20671696

 

 

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Cyfip1 is a putative invasion suppressor in epithelial cancers

Silva JM1, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ.

Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013.

PMID:19524508

 

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Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E.

Cell. 2009 Mar 20;136(6):1122-35. doi: 10.1016/j.cell.2008.12.043.

PMID:19303854

 

 

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Chromatin immunoprecipitation to study protein-DNA interactions in budding yeast

Ezhkova E1, Tansey WP.

Methods Mol Biol. 2006;313:225-44.

PMID:16118437

 

 

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The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators

Lee D, Ezhkova E, Li B, Pattenden SG, Tansey WP, Workman JL

Cell. 2005 Nov 4;123(3):423-36.

PMID:16118437

 

 

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Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3

Ezhkova E, Tansey WP.

Mol Cell. 2004 Feb 13;13(3):435-42

PMID: 14967150

 

 

 

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©  Updated September 24, 2019