Publications
Development and regeneration of Merkel cells
Yudong Zhou, Elena Ezhkova.
Curr Topics Dev Bio 2025, 165, 533-553. doi:10.1016/bs.ctdb.2025.03.008
Overview of chromatin regulatory processes during surface ectodermal development and homeostasis
Meagan C. Branch, Madison Weber, Meng-Yen Li, Pooja Flora, Elena Ezhkova.
Dev Bio 2024, 515, 30-45. doi:10.1016/j.ydbio.2024.07.001
Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages
Minh Binh Nguyen, Pooja Flora, Meagan C Branch, Madison Weber, Xiang Yu Zheng, Unnikrishnan Sivan, Simon Joost, Karl Annusver, Deyou Zheng, Maria Kasper, Elena Ezhkova
Sci Adv 2024, 10(3), eadi5791. doi:10.1126/sciadv.adi5791
Defining the fate trajectory of eccrine gland formation
Updates in SJS/TEN: collaboration, innovation, and community
Cleavage Under Targets & Release Using Nuclease (CUT&RUN) of Histone Modifications in Epidermal Stem Cells of Adult Murine Skin
Merkel Cell Polyomavirus-mediated reprorgramming in adult Merkel cell progenitors.
Madison Weber, Minh Nguyen, Meng-Yen Li, Pooja Flora, Masahiro Shuda, Elena Ezhkova.
Journ Invest Derm 2023, 143(11), 2163-76. doi: 10.1016/j.jid.2023.04.031
Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus
Michelle Khattri, Yutaka Amako, Julia R Gibbs, Joseph L Collura, Reety Arora, Alexis Harold, Meng Yen Li, Paul W Harms, Elena Ezhkova, Masahiro Shuda
Tumour Virus Research 2023, 16(200264). doi: 10.1016/j.tvr.2023.200264
Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration
Pooja Flora, Meng-Yen Li, Phillip M. Galbo Jr., Maider Astorkia, Deyou Zheng, and Elena Ezhkova.
PLoS Genet 2021, 17(12), e1009948. doi: 10.1371/journal.pgen.1009948
Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells
Pooja Flora, Gil Dalal, Idan Cohen, and Elena Ezhkova
Genes 2021, 12(10), 1485. doi: 10.3390/genes12101485
UV-induced reduction in Polycomb repression promotes epidermal pigmentation
Meng-Yen Li, Pooja Flora, Hong Pu, Carmit Bar, Jose Silva, Idan Cohen, Phillip M Galbo Jr, Hequn Liu 5, Xufen Yu, Jian Jin, Haruhiko Koseki, John A D'Orazio, Deyou Zheng, Elena Ezhkova
Dev Cell. 2021 Aug 30;S1534-5807(21)00636-5. doi: 10.1016/j.devcel.2021.08.006.
Polycomb complexes redundantly maintain epidermal stem cell identity during development
Idan Cohen, Carmit Bar, Hequn Liu, Victor J Valdes, Dejian Zhao, Phillip M Galbo Jr, Jose M Silva, Haruhiko Koseki, Deyou Zheng, Elena Ezhkova
Genes Dev, 18 Feb 2021, doi: 10.1101/gad.345363.120
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis
Development, Nov 15, 2020; 147(22):dev194100. doi: 10.1242/dev.194100.
Chromatin Immunoprecipitation of Low Number of FACS-Purified Epidermal Cells
Bar C, Valdes VJ, Ezhkova E.
Methods Mol Biol. 2020;2154:197-215. doi: 10.1007/978-1-0716-0648-3_17
Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions
Cohen I, Bar C, Ezhkova E.
Bioessays. 2020 Mar 20:e1900192. doi: 10.1002/bies.201900192
Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M
Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201907154. doi: 10.1073/pnas.1907154116
Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression
Bar C, Cohen I, Zhao D, Pothula V, Litskevitch A, Koseki H Zheng D, Ezhkova E.
Cell Rep. 2019 Jul 2;28(1):257-266.e5. doi: 10.1016/j.celrep.2019.06.011
Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
Miroshnikova YA, Cohen I, Ezhkova E, Wickström SA.
Curr Opin Genet Dev. 2019 May 18;55:46-51. doi: 10.1016/j.gde.2019.04.014
Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signaling
Nguyen MB, Valdes VJ, Cohen I, Pothula V, Zhao D, Zheng D, Ezhkova E.
Exp Dermatol. 2019 Feb 13. doi: 10.1111/exd.13901
PRC1 preserves epidermal tissue integrity independently of PRC2
Cohen I, Zhao D, Menon G, Nakayama M, Koseki H, Zheng D, Ezhkova E.
Genes Dev. 2018 Dec 19. doi: 10.1101/gad.319939.118
FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E.
Nat Commun. 2018 Jun 13;9(1):2333. doi: 10.1038/s41467-018-04399-y.
PMID: 29899403
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB1, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E
Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005.
PMID: 29727681
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
Rodriguez-Barrueco R1,2, Nekritz EA1, Bertucci F3, Yu J4, Sanchez-Garcia F5, Zeleke TZ1, Gorbatenko A1, Birnbaum D3, Ezhkova E6, Cordon-Cardo C1, Finetti P3, Llobet-Navas D1,2, Silva JM1
Genes Dev. 2017 Mar 15;31(6):553-566. doi: 10.1101/gad.292318.116
PMID:28404630
Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog
Zhang B, Tsai PC, Gonzalez-Celeiro M, Chung O, Boumard B, Perdigoto CN, Ezhkova E, Hsu YC.
Genes Dev. 2016 Oct 15;30(20):2325-2338. Epub 2016 Nov 2.
PMID: 27807033
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E
PLoS Genet. 2016 Jul 14;12(7):e1006151. doi: 10.1371/journal.pgen.1006151. eCollection 2016 Jul
PMID:27414999
The mesenchymal transcription factor SNAI-1 instructs human liver specification
Goldman O, Valdes VJ, Ezhkova E Gouon-Evans V
Stem Cell Res. 2016 Jul;17(1):62-8. doi: 10.1016/j.scr.2016.05.007. Epub 2016 May 21.
PMID:27240252
Molecular Mechanisms Regulating Stem Cells Fate
Chen YG, Ezhkova E, Ostankovitch M.
J Mol Biol. 2016 Apr 10;428(7):1407-8. doi: 10.1016/j.jmb.2016.03.011. Epub 2016 Mar 18
PMID:26996938
Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development
Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E.
J Invest Dermatol. 2016 Aug;136(8):1647-55. doi: 10.1016/j.jid.2016.02.809. Epub 2016 Mar 16.
PMID:26994968
Cbx4: A new guardian of p63's domain of epidermal control.
Cohen I, Ezhkova E
J Cell Biol. 2016 Jan 4;212(1):9-11. doi: 10.1083/jcb.201512032. Epub 2015 Dec 28
PMID:26711501
Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2
Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF
Genes Dev. 2015 Jan 15;29(2):144-56. doi: 10.1101/gad.249748.114. Epub 2014 Dec 29
PMID:25547114
Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network
Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E
Development. 2014 Dec;141(24):4690-6. doi: 10.1242/dev.112169
PMID:25468937
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells
Llobet-Navas D, Rodriguez-Barrueco R, de la Iglesia-Vicente J, Olivan M, Castro V, Saucedo-Cuevas L, Marshall N, Putcha P, Castillo-Martin M, Bardot E, Ezhkova E, Iavarone A, Cordon-Cardo C, Silva JM.
Mol Cell Biol. 2014 Dec 1;34(23):4216-31. doi: 10.1128/MCB.00611-14. Epub 2014 Sep 29
PMID:25266660
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland
Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM
Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17
PMID:24636986
Epigenetic regulation of epidermal differentiation
Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E.
Cold Spring Harb Perspect Med. 2014 Feb 1;4(2). pii: a015263. doi: 10.1101/cshperspect.a015263
PMID:24492849
Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
Bardot ES, Valdes VJ, Zhang J, Perdigoto CN, Nicolis S, Hearn SA, Silva JM, Ezhkova E.
EMBO J. 2013 Jul 17;32(14):1990-2000. doi: 10.1038/emboj.2013.110. Epub 2013 May 14
PMID:23673358
SWItching on epidermal cell fate
Perdigoto CN1, Bardot ES, Ezhkova E.
Cell Stem Cell. 2013 Feb 7;12(2):141-2. doi: 10.1016/j.stem.2013.01.011.
PMID:23395438
Epigenetic regulation of skin: focus on the Polycomb complex
Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E
Cell Mol Life Sci. 2012 Jul;69(13):2161-2172. doi: 10.1007/s00018-012-0920-x
PMID:22314499
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.
Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.
PMID:21680712
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E.
Genes Dev. 2011 Mar 1;25(5):485-98. doi: 10.1101/gad.2019811. Epub 2011 Feb 11
PMID:21317239
Regenerative medicine: An eye to treating blindness
Ezhkova E, Fuchs E.
Nature. 2010 Jul 29;466(7306):567-8. doi: 10.1038/466567a
PMID:20671696
Cyfip1 is a putative invasion suppressor in epithelial cancers
Silva JM1, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ.
Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013.
PMID:19524508
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E.
Cell. 2009 Mar 20;136(6):1122-35. doi: 10.1016/j.cell.2008.12.043.
PMID:19303854
Chromatin immunoprecipitation to study protein-DNA interactions in budding yeast
Ezhkova E1, Tansey WP.
Methods Mol Biol. 2006;313:225-44.
PMID:16118437
The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators
Lee D, Ezhkova E, Li B, Pattenden SG, Tansey WP, Workman JL
Cell. 2005 Nov 4;123(3):423-36.
PMID:16118437
