Publications
Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells
Pooja Flora, Gil Dalal, Idan Cohen, and Elena Ezhkova
Genes 2021, 12(10), 1485. doi: 10.3390/genes12101485
UV-induced reduction in Polycomb repression promotes epidermal pigmentation
Meng-Yen Li, Pooja Flora, Hong Pu, Carmit Bar, Jose Silva, Idan Cohen, Phillip M Galbo Jr, Hequn Liu 5, Xufen Yu, Jian Jin 6, Haruhiko Koseki, John A D'Orazio, Deyou Zheng, Elena Ezhkova
Dev Cell. 2021 Aug 30;S1534-5807(21)00636-5. doi: 10.1016/j.devcel.2021.08.006.
Polycomb complexes redundantly maintain epidermal stem cell identity during development
Idan Cohen* , Carmit Bar*, Hequn Liu, Victor J Valdes, Dejian Zhao, Phillip M Galbo Jr, Jose M Silva, Haruhiko Koseki, Deyou Zheng, Elena Ezhkova
Genes Dev, 18 Feb 2021, doi: 10.1101/gad.345363.120
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis
Development, Nov 15, 2020; 147(22):dev194100. doi: 10.1242/dev.194100.
Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M
Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201907154. doi: 10.1073/pnas.1907154116
Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
Miroshnikova YA, Cohen I, Ezhkova E, Wickström SA.
Curr Opin Genet Dev. 2019 May 18;55:46-51. doi: 10.1016/j.gde.2019.04.014
FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E.
Nat Commun. 2018 Jun 13;9(1):2333. doi: 10.1038/s41467-018-04399-y.
PMID: 29899403
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB1, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E
Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005.
PMID: 29727681
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
Rodriguez-Barrueco R1,2, Nekritz EA1, Bertucci F3, Yu J4, Sanchez-Garcia F5, Zeleke TZ1, Gorbatenko A1, Birnbaum D3, Ezhkova E6, Cordon-Cardo C1, Finetti P3, Llobet-Navas D1,2, Silva JM1
Genes Dev. 2017 Mar 15;31(6):553-566. doi: 10.1101/gad.292318.116
PMID:28404630
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E
PLoS Genet. 2016 Jul 14;12(7):e1006151. doi: 10.1371/journal.pgen.1006151. eCollection 2016 Jul
PMID:27414999
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells
Llobet-Navas D, Rodriguez-Barrueco R, de la Iglesia-Vicente J, Olivan M, Castro V, Saucedo-Cuevas L, Marshall N, Putcha P, Castillo-Martin M, Bardot E, Ezhkova E, Iavarone A, Cordon-Cardo C, Silva JM.
Mol Cell Biol. 2014 Dec 1;34(23):4216-31. doi: 10.1128/MCB.00611-14. Epub 2014 Sep 29
PMID:25266660
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland
Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM
Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17
PMID:24636986
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.
Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.
PMID:21680712